Incidence of penile neoplasia associated with the use of pesticides in the Irrigated Perimeter Jaguaribe Apodi - Ceará, Brazil: An in silico approach

The insertion of irrigated perimeters and the intensive use pesticides made Baixo Jaguaribe region one most critical areas agribusiness in Ceará. However, excessive has been associated with increased cases premature births, congenital malformations mainly neoplasms, especially penile cancer. Objective: To characterize silico triazine group used Jaguaribe-Apodi Irrigated Perimeter to investigate relationship between cancer pesticides. Methodology: It was given through molecular modeling using Classical Force Field (MMF94) obtain more stable structures physicochemical properties docking elucidate possible inhibition ligand (triazine)-protein (p53). Results: electronic structural characterization established that are soluble have no rotation, their double bonds derived from heterocyclic ring conformations stability energies relatively high. Conclusions: Regarding docking, ametryn atrazine likely initiate a carcinogenic response workers Perimeter, i.e., cancer, while cyromazine shows interactions p53 protein; thus, it does not act inhibitory potency.